What Is MOTS-c? The Mitochondrial-Derived Peptide Explained
MOTS-c is a 16-amino-acid mitochondrial-derived peptide sold for laboratory research use only. Here is what it is and how to verify a COA.
MOTS-c is a small peptide of 16 amino acids that is encoded within mitochondrial DNA rather than the cell nucleus, which makes it part of a class called mitochondrial-derived peptides. It is sold for laboratory research use only.
What makes MOTS-c unusual
Most peptides in the body are encoded by nuclear DNA. MOTS-c is different: it is encoded within a region of mitochondrial DNA. That origin places it in the same mitochondrial-derived peptide family as humanin.
Research-use status
Published literature on MOTS-c is mostly animal and cell work, and this page does not summarise effects or uses. MOTS-c is sold strictly as a research compound, not an approved therapeutic.
COA considerations for MOTS-c
As a defined-sequence peptide, MOTS-c can be confirmed by mass spectrometry for identity and HPLC for purity. A trustworthy COA names the lab, reports purity with decimal precision, and ideally includes endotoxin testing for any product intended for injection in a research setting.
What to check before buying
Verify a named third-party lab, a purity percentage that matches the label claim, a recent test date, and a verification key or portal where the lab supports one. Treat unnamed-lab purity claims as unverified.
Frequently Asked Questions
How many amino acids is MOTS-c?
MOTS-c is a 16-amino-acid peptide. Its defined sequence means identity can be confirmed by mass spectrometry on a proper COA.
Is MOTS-c approved for human use?
No. MOTS-c is sold as a research compound only and is not an approved drug. Nothing on this site is medical advice.
What should a good MOTS-c COA include?
A named lab, HPLC purity with decimals, mass-spec identity confirmation, and ideally endotoxin testing, with a verification key where available.